In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastric ulcer in rats.
RatChemical/toxinSprague-Dawleyn = Seven groups of 6 rats each, total 42Oral50, 100, 200 and 400 mg/kg in 0.5% carboxymethylcellulose,…Pretreatment 1 h before ethanol challenge
Model: Ethanol-induced gastric mucosal ulcer: 24 h fast then oral absolute ethanol, euthanasia 1 h later
The extract dose-dependently reduced ulcer area and mucosal damage, increased gastric mucus, glutathione and superoxide dismutase, reduced malondialdehyde, upregulated HSP70 and downregulated BAX.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.