The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.
MouseIschaemia-reperfusionIntestinal / mesentericC3aR-deficient and wild-type mice
Model: Neutrophil-dependent intestinal ischaemia-reperfusion injury
A potent C3a agonist reduced neutrophil mobilisation and ameliorated intestinal ischaemia-reperfusion pathology in wild-type but not C3aR-deficient mice.
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