Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 (also angptl4-deficient mice)Male
Model: Transient middle cerebral artery occlusion (transient ischaemic stroke model)
Recombinant ANGPTL4 significantly decreased infarct size, preserved vascular network density and interendothelial junction integrity, reduced brain oedema and inflammation, prevented neuronal loss in the ischaemic area and improved behaviour. Angptl4-deficient mice showed increased vascular damage…
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