Effects of biliverdin administration on acute lung injury induced by hemorrhagic shock and resuscitation in rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = n = 11 per group in the four-group pre-treatment protocol;…Intravenous (tail vein for pre-treatment; femoral vein for post-resuscitation treatment)35 mg/kg in 1 mL saline (approximately 20 mM), selected aft…1 h before haemorrhagic shock induction or sham surgery in the main protocol, a…
Model: Haemorrhagic shock (bled to mean arterial pressure 30 mmHg maintained for 60 min) followed by resuscitation with shed blood, causing acute lung injury
Biliverdin given before haemorrhagic shock and resuscitation significantly reduced histopathological lung damage, neutrophil infiltration and oedema, lowered the 18-fold and 8-fold increases in tumour necrosis factor-alpha and inducible nitric oxide synthase expression, and returned mitochondrial 8…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.