Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis.
RatChemical/toxinSprague-DawleyMalen = 90 rats divided equally into five groups40 mg/kgAdministered before establishment of the cholestasis model
Model: Alpha-naphthylisothiocyanate (ANIT) 50 mg/kg given intragastrically to induce acute cholestasis
Corilagin improved living condition, liver histopathology and total and direct bilirubin, reduced myeloperoxidase, malondialdehyde and NF-kappaB translocation and increased superoxide dismutase and nitric oxide, with no effect on ALT or AST.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.