Human growth hormone may be detrimental when used to accelerate recovery from acute tendon-bone interface injuries.
RatOtherSprague-Dawleyn = 72 rats in protocol 1 and 24 rats in protocol 2SubcutaneousProtocol 1: 0.1, 1, 2, 5 and 10 mg/kg/day. Protocol 2: 5 mg…Protocol 1 postoperative only; protocol 2 from seven days preoperatively until…
Model: Surgical repair of acute rotator cuff (tendon-to-bone) injury
Postoperative human growth hormone for fourteen days produced no significant biomechanical difference from placebo, while the longer twice-daily 5 mg/kg regimen gave lower ultimate force to failure (21.1 versus 26.3 N, p = 0.035) and more frequent failure through bone.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.