Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Intracarotid infusionThree hours after transient middle cerebral artery occlusion
Model: Transient middle cerebral artery occlusion (tMCAO) ischaemic stroke
Cultured immature dendritic cells homed transiently and selectively to the injured hemisphere, persisting at 3 h and gone by 24 h, with 2 to 3 per cent of radiolabelled cells at the injured side of the head, and cells loaded with therapeutic cargo suppressed initial neuron death.
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