PRECLINICAL PUBLICATION · 2013

Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

MMS350, a water-soluble oxetanyl sulfoxide

PMID 23606683 ↗2013Reported benefit

Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice.

MouseRadiationC57BL/6NTac

Model: Thoracic irradiation causing late pulmonary fibrosis

RNA and micro-RNA expression correlated with fibrosis, and MMS350 reduced pro-fibrotic gene expression in both pulmonary endothelial and alveolar type-II cells of irradiated mice; conditioned medium from irradiated cells did not alter cell motility in vitro.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.