Blockade of interleukin-6 receptor suppresses inflammatory reaction and facilitates functional recovery following olfactory system injury.
MouseOtherTransgenic mice with a reporter labelling olfactory nerve fibresMale and femaleIntraperitonealImmediately after nerve transection
Model: Severe olfactory nerve transection
Antibody-treated mice had significantly smaller injury-associated tissue areas, fewer astrocytes and macrophages/microglia, more regenerating nerve fibres and improved olfactory behavioural and evoked potential recovery.
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