Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6JMaleIntragastric gavage7.5, 15 or 30 micrograms per mousePretreatment for three weeks before induction of ischaemia
Model: Temporary focal cerebral ischaemia in non-diabetic mice
The 15 microgram dose significantly reduced infarct volume (p = 0.009) and neurological deficit (p = 0.004) at 24 h, persisting into the chronic phase, while the 7.5 and 30 microgram doses did not; brain-derived neurotrophic factor was elevated in cortex and whole forebrain before ischaemia.
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