Flagellin or lipopolysaccharide treatment modified macrophage populations after colorectal radiation of rats.
RatRadiationSprague-DawleyMaleIntraperitoneal50 or 200 micrograms per ratThree days after irradiation
Model: Single 20 or 27 Gy dose of colorectal irradiation
Irradiation increased TLR4+ and TLR5+ macrophage frequency, and flagellin or lipopolysaccharide maintained this elevation after 27 Gy while shifting macrophages towards an M2 phenotype, correlating with epithelial regeneration.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.