Different methods of immunosuppresion do not prolong the survival of human cord blood-derived neural stem cells transplanted into focal brain-injured immunocompetent rats.
RatChemical/toxinWistarMaleCyclosporine A and azathioprine intraperitoneal, methylprednisolone intramuscular; cells transplanted into the brainCyclosporine A 10 mg/kg; azathioprine 5 mg/kg; methylpredni…
Model: Focal brain injury with cerebral infarct in immunocompetent rats, produced using ouabain
Transplanted cell numbers fell gradually with complete disappearance by day 14 in all groups and no difference between immunosuppressive regimes; the innate immune response dominated and peaked at day 3.
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