Cerebral ischemia-induced difference in sensitivity to depression and potential therapeutics in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleAcute administration during the induction phase; chronic bryostatin-1 given aft…
Model: Single episode of cerebral ischaemia followed by open space swim test to assess depressive behaviour
Acute BDNF or bryostatin-1 during induction reduced ischaemia-induced depressive sensitivity, and 5 weeks of bryostatin-1 reversed depressive immobility with a lasting effect persisting 3 weeks after treatment stopped, whereas alaproclate gave only temporary relief.
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