PRECLINICAL PUBLICATION · 2013

Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Cytoglobin (CYGB) overexpression by adenoviral cDNA delivery (Cygb-cDNA-ADV), with Cygb-shRNA-ADV knockdown

PMID 23585565 ↗2013Reported benefit

Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMale and femaleIntracerebral injection4 days before hypoxia-ischaemia

Model: Neonatal hypoxia-ischaemia brain injury

Up-regulation of cytoglobin reduced acute brain injury, raised superoxide dismutase and VEGF, increased microvessel density and diameter, inhibited caspase-2 and -3 activation, and improved long term cognitive performance.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.