Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury.
RatTBIWeight-drop / impact-accelerationWistarMalen = 60 rats (30 saline, 30 Cerebrolysin)Intraperitoneal2.5 ml/kgStarting 1 hour post-injury
Model: Impact acceleration-induced closed head injury
Cerebrolysin improved all functional outcomes at 14 days, increased neurons and neuroblasts in the dentate gyrus, preserved axonal integrity in the striatum, increased perfused vessels and VEGF-positive cells and reduced MMP-9 staining, although MMP-9 and VEGF mRNA did not differ at 48 hours.
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