Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism.

Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism.

Model: Formalin injection into the paw producing acute inflammatory pain

Platelet-rich plasma, its lipid extract and the endocannabinoid-enriched fraction each produced potent antinociception against both early and late phases, and this was abolished by local CB1 and CB2 antagonists, indicating a peripheral endocannabinoid mechanism.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.