Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats.
RatOtherWistarMaleOral100 mg/kgAdministered after spinal nerve ligation surgery, with both prophylactic and th…
Model: Spinal nerve ligation model of chronic peripheral nerve injury
LASSBio-873 inhibited the development of thermal hyperalgesia and mechanical allodynia and reversed established symptoms without altering open field behaviour; the effect was blocked by intrathecal methoctramine.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.