The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6Male10 mg/kg and 2 mg/kg2 hours after 60 minutes of tMCAO
Model: 60 minutes of transient middle cerebral artery occlusion (tMCAO) with reperfusion
Rolipram 10 mg/kg reduced infarct volume by 50% and improved clinical scores at day 1, preserved blood-brain barrier tight junctions, reduced oedema, inflammation, thrombosis and apoptosis, whereas 2 mg/kg had no effect.
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