Effect of low-level laser therapy (LLLT) on acute neural recovery and inflammation-related gene expression after crush injury in rat sciatic nerve.
RatCrushPeripheral-nerve crushWistarMalen = 30 rats in three groupsTranscutaneous irradiation of the injured nerve60 J/cm2 at 40 mW/cm2, 660 nmApplied during the acute phase, with assessment 3 days post-injury
Model: Sciatic nerve crush injury
Low-level laser therapy increased MMP activity, mainly MMP-9, and TNF-alpha protein during the acute phase, which the authors interpret as modulation of inflammation, but no functional recovery outcome was reported at this time point.
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