Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice.
MouseRadiationC57BL/6Malen = 12 mice (6 nicaraven, 6 placebo)Intraperitoneal100 mg/kg/dayGiven soon after each of the five daily radiation exposures
Model: Whole-body gamma-ray irradiation, 1 Gy daily for 5 successive days (total 5 Gy) from a caesium source at 0.86 Gy/min
Post-radiation nicaraven increased peripheral nucleated cells and c-kit and CD34 positive cells, increased bone marrow colony formation, reduced 53BP1 foci and lowered urinary 8-OHdG and plasma IL-6 and TNF-alpha, although intracellular and mitochondrial reactive oxygen species and plasma 8-OHdG di…
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