Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response.
RatIschaemia-reperfusionRenalSprague-DawleyMaleIntraperitoneal40 mg/kg30 minutes before induction of ischaemia-reperfusion
Model: Clamping of the left renal artery for 45 minutes followed by 12 hours of reperfusion and contralateral nephrectomy
Osthole pre-treatment improved renal function and histology and reduced neutrophil and monocyte/macrophage infiltration and inflammatory mediator expression after renal ischaemia-reperfusion.
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