Acute stimulation of transplanted neurons improves motoneuron survival, axon growth, and muscle reinnervation.
RatOtherFischer (F344)FemaleTransplantation into the distal tibial nerve stumpStimulation immediately post-transplantation
Model: Sciatic nerve transection producing widespread motoneuron denervation, with transplantation into the distal tibial nerve stump
Acute 20 Hz stimulation increased the number of surviving transplanted neurons including cholinergic neurons at 10 weeks, increased myelinated axons and reinnervated muscle fibres, connected more gastrocnemius muscles to the transplant and significantly reduced muscle atrophy.
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