Simvastatin reduces VEGF and NO levels in acute stages of experimental traumatic brain injury.
RatTBIUnspecifiedWistar albinoMalen = 40 rats in four groups1 mg/kg3 hours after the injury insult
Model: Experimentally induced traumatic brain injury
Simvastatin significantly reduced histopathological brain injury scores and prevented the trauma-induced rises in serum and brain VEGF and brain nitric oxide at 24 hours.
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