Creation of lung-targeted dexamethasone immunoliposome and its therapeutic effect on bleomycin-induced lung injury in rats.
RatChemical/toxinSprague-Dawley (specific pathogen free)Malen = Therapeutic study of 60 rats in six groups of 10, split int…Intravenous (tail vein)1 mg/kg and 0.5 mg/kg dexamethasone sodium phosphate equiva…Started after establishment of the injury model
Model: Bleomycin-induced acute lung injury by endotracheal injection of 5 mg/kg bleomycin; the survival study used 10 mg/kg endotracheally
SPA-DXM-NLP gave 5.1-fold higher peak lung dexamethasone and 40.2-fold higher lung AUC than free dexamethasone and, at two weeks, improved lung injury scores, lowered bronchoalveolar TNF-alpha and TGF-beta1, eliminated positive cultures and raised 8 week survival to 83.3 per cent versus 33.3 per ce…
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