Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
MouseOtherSestrin 2 knockout (Sesn2-/-) mice and wild-type controls; 129 strain and C57BL backgrounds per MeSH indexingMale and female
Model: Spared nerve injury model of neuropathic pain; acute nociceptive and inflammatory (zymosan) pain models also used
Sesn2 was upregulated in peripheral nerves after spared nerve injury, and Sesn2 knockout mice showed considerably increased late-phase neuropathic pain behaviour with elevated reactive oxygen species and enhanced activating transcription factor 3 upregulation. The exacerbated phenotype was reversed…
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