Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung.
RatRadiationWAG/RijCmcrFemalen = 13 Gy alone n = 8; enalapril 60 mg/L n = 40 and 30 mg/L n =…Oral, in drinking water30 or 60 mg/L in drinking water, reported to deliver 12.5 t…Started at 1, 5, 10, 15 or 20 weeks after irradiation
Model: Single dose of 5 to 13 Gy X-rays to the whole thorax (320 kVp orthovoltage, half-value layer 1.4 mm Cu, dose rate 1.43 Gy/min, two equally weighted lateral beams); late lung injury assessed 20 to 71 weeks after irradiation
Enalapril reduced radiation-induced pulmonary cholesterol clefts from 18.7 plus or minus 4.2 per lung section to 6.8 plus or minus 2.4 (p = 0.029), 5.2 plus or minus 1.9 (p = 0.0051) and 6.7 plus or minus 1.9 (p = 0.029) when started at 1, 5 and 15 weeks after 13 Gy. Pooled analysis confirmed mitig…
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