Standing frame and electrical stimulation therapies partially preserve bone strength in a rodent model of acute spinal cord injury.
RatSpinal cord injuryComplete transectionWistarMalen = Sham n = 10; spinal cord injury n = 7; injury plus standing…Not applicable (physical therapy and electrical stimulation)20 minutes per day, 3 days per week, for 30 daysTherapies initiated 3 days after surgery
Model: Complete spinal cord injury by surgical transection at the T10 level
Neither therapy preserved bone mineral density at any site (p = 0.08 to 0.99). Standing frame therapy preserved maximal load at the lumbar vertebral body (14 percent versus 37 percent reduction, p = 0.01) and prevented loss of stiffness at the femur (8 percent versus 37 percent, p = 0.03) and tibia…
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