Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
MixedTBIControlled cortical impactCongenic global adenosine A2A receptor knockout mice on a C57BL/6 background and wild-type littermates, plus bone marrow chimerasn = n = 8 to 10 per group for lung injury parameters, each expe…Agonist 0.1 mg/kg; antagonist ZM241385 1 mg/kgGiven 3 hours after traumatic brain injury
Model: Severe traumatic brain injury by weight-drop cortical impact causing neurogenic acute lung injury (neurological deficit score III, about 30 percent mortality within 5 minutes); a moderate weight-drop model and a non-neurogenic oleic acid model (0.6 ml/kg intravenous) were used for comparison
In severe traumatic brain injury-induced acute lung injury the A2A receptor agonist worsened lung water content, PaO2/FiO2 ratio, histological injury and neutrophil infiltration, while the antagonist ZM241385 attenuated all of these, with no effect in A2A receptor knockout mice. The direction was o…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.