Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6NMaleSubcutaneous injectionBortezomib 0.2 mg/kg plus dexamethasone 10 mg/kg30 minutes after injury
Model: Mechanical brain lesion by controlled cortical impact
Proteasomal glucocorticoid receptor degradation was established in brain endothelial cells after controlled cortical impact. Combining bortezomib with dexamethasone restored occludin levels, improved blood-brain barrier integrity, reduced oedema formation and limited neuronal damage, offering a mec…
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