Surgical incision induces phosphorylation of AMPA receptor GluR1 subunits at Serine-831 sites and GluR1 trafficking in spinal cord dorsal horn via a protein kinase Cgamma-dependent mechanism.
RatWoundSprague-DawleyMaleIntrathecalPretreatment before surgical incision
Model: Surgical plantar incision model of postoperative pain
Plantar incision increased membrane translocation of PKCgamma but not PKCalpha, betaI or betaII, and induced GluR1 but not GluR2 trafficking into the neuronal plasma membrane. Intrathecal PKCgamma siRNA pretreatment reduced spinal PKCgamma expression, significantly attenuated pain hypersensitivity,…
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