Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone.
RatSpinal cord injuryContusionSprague-DawleyMalen = n = 8 for each of the three injured groups (MnTBAP, methylp…Intrathecal via implanted catheter, and intraperitoneal4 mg/kg intrathecally for reactive oxygen species and neuro…Intrathecal dose immediately after injury, completed within about 10 minutes; b…
Model: Traumatic spinal cord contusion with the New York University impactor; behavioural cohort injured at T10 with a 10 g rod dropped 2.5 cm (25 g.cm), histology cohort at T13 with a 10 g rod dropped 1.25 cm (12.5 g.cm)
MnTBAP scavenged both hydrogen peroxide and superoxide after spinal cord injury, whereas methylprednisolone reduced hydrogen peroxide only and scavenged neither species in vitro, and MnTBAP significantly reduced 4-hydroxy-nonenal-positive and nitrotyrosine-positive neurons rostral to the epicentre.…
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