Tetramethylpyrazine prevents contrast-induced nephropathy by inhibiting p38 MAPK and FoxO1 signaling pathways.

Tetramethylpyrazine prevents contrast-induced nephropathy by inhibiting p38 MAPK and FoxO1 signaling pathways.

Model: Contrast-induced nephropathy (acute kidney injury) induced by contrast medium

Tetramethylpyrazine significantly attenuated the renal dysfunction and renal tubular cell apoptosis caused by contrast medium. Mechanistically it decreased phospho-p38 MAPK, attenuated the rise in FoxO1 mRNA and nuclear protein, inhibited inducible nitric oxide synthase and Bax, and upregulated Bcl…

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