Neutrophil-derived tumor necrosis factor-alpha contributes to acute wound healing promoted by N-(3-oxododecanoyl)-L-homoserine lactone from Pseudomonas aeruginosa.
RatWoundSprague-DawleyMaleApplied at the wound surface; anti-3-oxo-C12-HSL antiserum given intraperitoneally
Model: Full-thickness dorsal skin wounds inoculated with Pseudomonas aeruginosa strain PAO1 or its lasI deletion mutant
Inoculation with PAO1 significantly accelerated wound healing and the inflammatory response at day 3, an effect lost with the lasI mutant or with anti-3-oxo-C12-HSL antiserum. Administration of 3-oxo-C12-HSL alone promoted the same responses, and these were suppressed by anti-tumour necrosis factor…
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