Simvastatin maintains function and viability of steatotic rat livers procured for transplantation.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMaleDonor pretreatment (route not stated in the abstract)Single dose (amount not stated in the abstract)30 minutes before liver procurement
Model: Steatotic liver grafts from high-fat diet fed donors subjected to 16 hours cold storage and warm reperfusion (0 hours cold storage as control)
Cold-stored steatotic livers showed raised hepatic vascular resistance, endothelial dysfunction, liver damage, oxidative stress and low nitric oxide. Simvastatin donor pretreatment markedly improved liver injury and prevented endothelial dysfunction, with reduced cell death, autophagy induction and…
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