Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion.
RatTBIFluid percussionLong-Evans hoodedMalen = 87 rats in total; sham-SR n=15, 1B7-SR n=15, CD11d-SR n=15,…Intravenous (tail vein) injection1.0 mg/kg2 h after each injury
Model: Three repeated mild lateral fluid percussion injuries at 1 to 1.5 atm with a 5-day inter-injury interval
Anti-CD11d antibody reduced neutrophil and macrophage infiltration, astrogliosis, lipid peroxidation (33.3 versus 56.1 nmol/mg protein), amyloid precursor protein accumulation and neuronal loss, and improved cognition, anxiety-like behaviour and sensorimotor performance relative to 1B7 controls at…
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