Compositional characterisation of soluble apple polysaccharides, and their antioxidant and hepatoprotective effects on acute CCl4-caused liver damage in mice.
MouseChemical/toxinMaleOral administration250 and 500 mg/kg body weight
Model: Acute carbon tetrachloride-induced liver injury
Both apple peel and flesh polysaccharides lowered carbon tetrachloride-induced rises in serum transaminases, lactate dehydrogenase and hepatic malondialdehyde and antagonised falls in superoxide dismutase and glutathione peroxidase, with histology confirming protection.
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