PRECLINICAL PUBLICATION · 2013

Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Codium fragile butanol and ethyl acetate fractions and the isolated compound clerosterol

PMID 23396144 ↗2013Reported benefit

Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice.

MouseRadiationBALB/cMaleTopical application to skinApplied prior to UVB irradiation

Model: UVB irradiation of skin at 200 mJ/cm2 in vivo and 60 mJ/cm2 in HaCaT keratinocytes

Topical Codium fragile fractions and clerosterol inhibited UVB-induced increases in COX-2, iNOS and TNF-alpha and reduced lipid peroxidation and protein carbonylation in mouse skin, mirroring protection seen in HaCaT cells.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.