Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction.
RatIschaemia-reperfusionCardiacSprague-DawleyOralCandesartan 30 mg/kg/day; omapatrilat 10 mg/kg/dayStarted on day 2 after reperfused myocardial infarction
Model: Reperfused myocardial infarction with assessment during the healing phase to day 25
Both candesartan and omapatrilat attenuated infarct-related increases in SLPI, matricellular proteins, angiotensin II, inflammatory and matrix remodelling mediators and left ventricular remodelling, and normalised the fall in IL-10.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.