Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6Malen = n=5 per group for sham, vehicle and cRGDIntraperitoneal injection5 mg/kg body weight in 0.2 ml; a pilot dose of 10 mg/kg gav…1 h prior to ischaemia
Model: Intestinal ischaemia/reperfusion by superior mesenteric artery occlusion for 45 min followed by reperfusion, with tissues collected 4 h after reperfusion
cRGD reduced gut and lung injury scores by 70.6 and 60.0 per cent, cut gut and lung myeloperoxidase by 77.8 and 54.2 per cent, lowered serum TNF-alpha and IL-6 by 71.0 and 67.9 per cent and reduced lung TUNEL-positive cells by 59.5 per cent.
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