Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury.

Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury.

Model: Controlled cortical impact traumatic brain injury

Mild hypothermia partially blunted injury-induced CaSR overexpression, brain tissue loss and motor deficits, and the CaSR antagonist NPS89636 mimicked hypothermia in reducing tissue loss and motor dysfunction.

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