Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyUnsexed fetuses and male neonatesn = n=5 per group per time point prenatally and n=4 per group p…Surgical clamping of uterine and ovarian arteriesSingle 30 min uterine and ovarian artery clamping episodeEmbryonic day 17, approximately 96 h before birth and the perinatal asphyxia in…
Model: Perinatal asphyxia induced at term by placing uterine horns containing pups in 37 degrees Celsius saline for 19 min, preceded by fetal asphyctic preconditioning at embryonic day 17 by 30 min clamping of the uterine and ovarian arteries
Fetal asphyctic preconditioning altered the prenatal cytokine response, raising IL-6 mRNA and IL-10 protein by 96 h, and normalised the IL-10 and IL-6 mRNA rises seen after perinatal asphyxia, consistent with a protective inflammatory phenotype.
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