PRECLINICAL PUBLICATION · 2013

Mitigating effects of hUCB-MSCs on the hematopoietic syndrome resulting from total body irradiation.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs)

PMID 23333483 ↗2013Reported benefit

Mitigating effects of hUCB-MSCs on the hematopoietic syndrome resulting from total body irradiation.

MouseRadiationBALB/cFemaleAfter irradiation; exact interval not stated

Model: Total body irradiation, 7 Gy cobalt-60 gamma rays

hUCB-MSCs increased peripheral leukocyte, lymphocyte and monocyte recovery, increased bone marrow Ki-67 immunoreactivity at 3 weeks and modulated plasma Flt-3L and TGF-beta1 more effectively than G-CSF.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.