Blockade of CD47 increases survival of mice exposed to lethal total body irradiation.
MouseRadiationC57BL/6 wild typeIntraperitoneal10 microM CD47 morpholino in a 750 microlitre volume of sal…Pre-treatment arm dosed 48 h before irradiation; post-treatment arm dosed immed…
Model: Single dose total body irradiation of 7.6 Gy X-rays (300 kVp, 2.0 mm aluminium filtration) at 2.53 Gy/min; a separate arm used 7.6 Gy hindlimb irradiation
Pre-treatment with CD47 morpholino raised 30-day survival to 71.5 percent versus 21.4 percent for saline and 40 percent for mismatched morpholino, preserved bone marrow proliferative capacity and circulating lymphocytes and reduced gastrointestinal apoptosis.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.