PRECLINICAL PUBLICATION · 2013

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury.

Mouse / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Ilomastat

PMID 23281396 ↗2013Reported benefit

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)

Model: Prolonged cerebral hypoperfusion stress leading to white matter demyelination

GM6001 reduced early blood-brain barrier leakage and neutrophil infiltration after cerebral hypoperfusion, indicating that oligodendrocyte precursor derived MMP9 drives early barrier disruption.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.