Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6FemaleIntraspinal transplantation at the injury siteTransplantation at sites of spinal cord injury; depletion experiments used anti…
Model: Contusive spinal cord injury
Depletion of the Ly6C+ Ly6G- fraction worsened oedema, vessel permeability, haemorrhage and neurological outcome, and intraspinal transplantation of ex vivo-generated myeloid-derived suppressor cells reduced inflammation, promoted tissue regeneration and improved functional recovery.
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