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Open research access
PRECLINICAL PUBLICATION · 2013

Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 23270472 ↗2013Reported benefit

Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation.

MouseRadiationCD2F1MaleIntravenous transfusion5 million peripheral blood mononuclear cells per recipientAfter irradiation; exact interval not stated

Model: Whole body gamma irradiation at a high dose; exact dose not stated in abstract

Infusion of alpha-tocopherol succinate and AMD3100 mobilised peripheral blood mononuclear cells inhibited apoptosis, increased cell proliferation in intestine and spleen and reduced bacterial translocation compared with vehicle-mobilised cells.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.