Effects of acute intrathecal baclofen in an animal model of TBI-induced spasticity, cognitive, and balance disabilities.
RatTBIWeight-drop / impact-accelerationSprague-DawleyIntrathecal, delivered by Alzet osmotic pump0.8 microgram per hourTreatment initiated at post-injury week 1
Model: Closed head traumatic brain injury using the Marmarou weight-drop model
One month of intrathecal baclofen begun at week 1 blocked early-onset spasticity, attenuated late-onset spasticity and anxiety-like behaviour without adverse effects on cognition or balance, and increased spinal GABA and GABA-B, noradrenaline and brain-derived neurotrophic factor expression.
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