Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Apolipoprotein E-deficientAcute treatment 5 min after cerebral ischaemia onset in the stroke model; chron…
Model: Carotid cast-induced atherosclerosis; transient left middle cerebral artery occlusion
Evasin-3 reduced neutrophilic inflammation in both models, with lower intraplaque neutrophil and matrix metalloproteinase-9 content and a weak increase in collagen in carotid atherosclerosis, and reduced brain neutrophil infiltration after stroke, but administration after ischaemia onset did not im…
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