Co-administration of prostaglandin E1 with somatostatin attenuates acute liver damage after massive hepatectomy in rats via inhibition of inflammatory responses, apoptosis and endoplasmic reticulum stress.

Co-administration of prostaglandin E1 with somatostatin attenuates acute liver damage after massive hepatectomy in rats via inhibition of inflammatory responses, apoptosis and endoplasmic reticulum stress.

Model: Acute liver damage after 90% hepatectomy

Pre-treatment with prostaglandin E1 and somatostatin, particularly in combination, improved survival and reduced portal venous pressure, transaminases and inflammatory cytokines, inhibited apoptosis through upregulated Bcl-2 with downregulated Bax and caspase-3, and alleviated endoplasmic reticulum…

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