Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair.
RatSpinal cord injuryHemisection / partialWistar (HanTac:WH)Femalen = 72 female rats (36 young, 36 geriatric) in 18 groups, 4 ani…Local injection into the spinal cord lesion site8 injections of 0.2 microlitres of 40 mM 2,2'-bipyridine-5,…Immediately after hemisection and dural suture
Model: Dorsal spinal cord hemisection including transection of the corticospinal tract with a Scouten wire knife at thoracic level 8 under isoflurane anaesthesia; laminectomy alone as sham
Cortical transcriptomes after spinal cord injury were largely age specific, with only about 7 per cent overlap of lesion-regulated genes between aged and young rats (2488 versus 753 regulated genes). At 35 days post-operation the anti-scarring treatment produced similar profiles in aged and young a…
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